Publications

Investigations funded by the Longer Life Foundation have resulted to date in 122 articles in peer-reviewed medical journals. Find them here.
View Peer-Reviewed Articles

2017 Publications

  • Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology


    Bertozzi B, Tosti V, Fontana L. 2017 Jan.; 63(1); 13-9.

  • Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism are Associated with Protein Ingestion-Induced Insulin Resistance. 


    Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade A, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B: Diabetes 2017 (PMID: 28473464) 


2016 Publications

  • Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound.


    Cyr AE, Tucker N, Ademuyiwa F et al. J Am Coll Surg.2016 Aug;223(2):399-407.

  • Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36.


    Love-Gregory L, Kraia AT, Allum F et al. J Lipid Res. 2016 Dec57(12):2176-84.

  • Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health.


    Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N, Pincus Z.
    Cell Systems, 2016 Oct 26;3(4):333-45.

  • NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice.


    Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J. Cell Reports. 2016 Aug 16;16(7):1851-60.

  • Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "Non-Cognitive" Outcomes of Alzheimer's Disease.


    Ingber AP, Hassenstab J, Fagan AM, Benzinger TL, Grant EA, Holtzman DM, Morris JC, Roe CM. J Alzheimers Dis. 2016;52(3):1055-64.

  • Human Metabolome-Derived Cofactors are Required for the Antibacterial Activity of Siderocalin in Urine.


    Shields-Cutler RR, Crowley JR, Miller CD, Stapleton AE, Cui W, Henderson JP.
    The Journal of Biological Chemistry. 2016 Oct. 25.

  • Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle.


    Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Cell Reports. 2016 Jan 26;14(3):422-8.

  • Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.


    Fontana L, Cummings NE, Arriola Apelo SI et al.  Cell Reports, 2016 Jul 12;16(2):520-30.

  • Calorie restriction in humans: An update.


    Most J, Tosti V, Redman LM, Fontana L.
    Ageing Res Rev., 2016 Aug 17.

  • High-protein intake during weight-loss therapy eliminates the weight loss-induced improvement in insulin action in obese postmenopausal women.


    Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B. Cell Reports. Oct. 11, 2016. 

  • Predicting all-cause mortality from basic physiology in the Framingham Heart Study


    Zhang WB, Pincus Z. Aging Cell, 2016 Feb 15. (1):39-48.

  • Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity


    Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S.
    Cell Metabolism, 2016 Feb 22. pii: S1550-4131(16)30053-5. doi: 10.1016/j.cmet.2016.02.005. [Epub ahead of print]

  • Probiotic Gut Bacteria Enhance Cancer Immunotherapy in a Mouse Model of Melanoma.


    Dey N, Ciorba MA.
    Gastroenterology. 2016 May 26. pii: S0016-5085(16)34458-4. doi: 10.1053/j.gastro.2016.05.015. [Epub ahead of print] No abstract available.

  • Long-Term Administration of Nicotinamide
    Mononucleotide Mitigates Age-Associated
    Physiological Decline in Mice


    Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, ..., Koji Uchida,
    Jun Yoshino, Shin-ichiro Imai
    Cell Metabolism, December 13, 2016 , 24, 1–12 [Epub ahead of print]

  • Combined associations of body weight and lifestyle factors with all-cause and cause-sepcific mortality in men and women: prospective cohort study.


    Veronese N, Li Y, Manson JE, Willett WC, Fonana L, Hu FB.
    BMJ 2016 Nov. 24; 355.

2015 Publications

  • Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss


    Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL, Klein S.
    Obesity, 2015 Feb; 23(2):329-34

     

  • Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer


    Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED
    Mayo Clinic Proceedings, 2015 Jan; 90(1):35-42

     

  • Evaluation of urine aquaporin-1 and perilipin-2 concentrations as biomarkers to screen for renal cell carcinoma: A prospective cohort study


    Morrissey JJ, Mellnick VM, Luo J, Siegel MJ, Figenshau RS, Bhayani S, Kharasch ED
    JAMA Oncology, 2015 May; 1(2):204-12

     

  • Human urinary composition controls antibacterial activity of siderocalin


    Shields-Cutler RR, Crowley JR, Hung CS, Stapleton AE, Aldrich CC, Marschall J, Henderson JP
    The Journal of Biological Chemistry, 2015 April 10, 

  • Promoting health and longevity through diet: from model organisms to humans


    Fontana L, Partridge L
    Cell, 2015 March 25; 161(1); 106-18

  • Calorie restriction, endothelial function and b¬lood pressure homeostasis


    Spelta F, Bertozzi B, Cominacini L, Fontana L
    Vascul Pharmacol, 2015 Feb-Mar, 65-6:1-2.

  • Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population


    Levine M, Suarez J, Brandhorst S, Balasubramanian, Cheng CW, Madia F, Fontana L, Mirisola MP, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins E, Longo VD
    Cell Metabolism 2014 Mar 4;19(3):407–17

  • Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action.


    Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ.
    Curr Opin Support Palliat Care. 2015 Jun;9(2):157-62. doi: 10.1097/SPC.0000000000000134. Review.
    PMID: 25872116

  • Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens.


    Parker KS, Wilson JD, Marschall J, Mucha PJ, Henderson JP.
    ACS Infect Dis. 2015 Nov 13;1(11):523-32.

  • “Noncognitive” symptoms of early Alzheimer disease: a longitudinal analysis.


    Masters MC, Morris JC, Roe CM.
    Neurology. 2015 Feb. 10; 84(6): 617-22.

2014 Publications

  • Energy requirements in nonobese men and women: results from CALERIE


    Redman LM, Kraus WE, Bhapkar M, Das SK, Racette SB, Martin CK, Fontana L, Wong WW, Robert SB, Ravussin E, for the CALERIE Study Group
    Am J Clin Nutr Jan 2014

  • Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population


    Levine ME, Suarez JA, Brandhorst S, Balasubramanian P; Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo, VD
    Cell Metabolism 19, 407-17, March 4, 2014   

  • Optimal body weight for health and longevity: bridging basic, clinical, and population research


    Fontana L, Hu FB
    Aging Cell (2014) pp 1-10

  • Postprandial plasma incretin hormones in exercise-trained versus untrained subjects


    Weiss EP, Royer NK, Fisher JS, Holloszy JO, Fontana L
    Med Sci Sports Exerc 2014 Jun; 46(6): 1098-103

  • Cytochrome P450 gene variants, race and mortality among clopidogrel-treated patients after acute myocardial infarction


    Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA,. Bach RG
    Circ Cardiovasc Genet 2014 Jun;7(3):277-86

  • Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade


    Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S, Figenshau RS , Kharasch ED
    Urology 2014 Jan;83(1): 256

  • Activation of miR-9 by human papillomavirus in cervical cancer


    Liu W, Gao g,, Hu X, Wang Y, Schwarz JK, Chen JJ, Grigsby PW, Wang X
    Oncotarget, 2014 Nov 30; 5(22):11620-30

  • CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction


    Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S
    Nicotine Tob Res 2014 Sep;16(9):1224-31

  • What are the roles of calorie restriction and diet quality in promoting healthy longevity?


    Rizza W, Veronese N, Fontana L
    Ageing Research Reviews 2014 Jan; 13:38-45   

  • Medical research: treat ageing


    Fontana L, Kennedy BK, Longo VD, Seals D, Melov S
    Nature 2014 Jul 24;511(7510):405-7

2013 Publications

  • Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later


    Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D; Sutphen CL, Benzinger TL, Mintun MA, Holtzman DM, Morris JC
    Neurology 2013 May 7;80(19):1784-91

  • The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma


    Morrissey JJ, Kharasch ED
    The Journal of Urology, 2013 May; 189(5):1913-20

  • Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire


    Carnero Pardo C, de la Vega Cotarelo R, López Alcalde S, Martos Aparicio C, Vilchez Carrillo R, Mora Gavilán E, Galvin JE
    Neurologia 2013 Mar;28(2):88-94

  • “Deficiency” of mitochondria in muscle does not cause insulin resistance


    Holloszy JO
    Diabetes 2013 Apr;62 (4): 1036-1040

  • Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile


    Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L
    Aging Cell 2013 Aug;12(4):645-51

  • Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model


    Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD
    Aging Cell 2013 Apr;12(2):257-6

  • Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients


    Fontana L, Addante F, Copetti M, Paroni G, Fontana A, Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A
    Aging Cell 2013 Jun;12(3):459-66

  • Will calorie restriction work in humans?


    Cava E, Fontana L
    Aging 2013 Jul;5(7):507-14

  • Serum from humans on long-term calorie restriction enhances stress resistance in cell culture


    Omodei D, Licastro D, Salvatore F, Crosby SD, Fontana L
    Aging 2013 Aug;5(8):599-606

  • Energy efficiency as a unifying principle for human, environmental, and global health


    Fontana L, Atella V, Kammen DM
    F1000Research 2013, 2:101

  • Multiple dietary supplements do not affect metabolic and cardiovascular health


    Soare A, Weiss EP, Holloszy JO, Fontana L
    Aging 2013 Sep 4 (Epub)

  • Dietary protein restriction inhibits tumor growth in human xenograft models


    Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R
    Oncotarget 2013 Dec;4(12):2451-61 

  • Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals


    Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S
    Gastroenterology 2013 Aug;145(2):366-74

  • CSF biomarkers of Alzheimer disease: “noncognitive” outcomes


    Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC
    Neurology 2013 Dec 3;81(23):2028-31

  • Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography


    Yoshino J, Imai S
    Methods Mol Biol 2013;1077:203-15

2012 Publications

  • An exploration of salivation patterns in normal weight and obese children


    Aspen VA, Stein RI, Wilfley DE
    Appetite 2012 Apr 58(2):539-42

  • Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults


    Villareal DT, Smith GI, Shah K, Mittendorfer B
    Obesity 2012 Sep;20 (9):1780-6

  • Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner


    Cresci S, Dorn GW 2nd, Jones PG, Beitelshees, AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE
    Journal of the American College of Cardiology 2012 Sep 4;60(10):898-907

  • Growth factors, nutrient signaling, and cardiovascular aging


    Fontana L, Vinciguerra M, Longo VD
    Circulation Research 2012 Apr 13;110(8):1139-50

  • Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss as compared to calorie restriction


    Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP
    Journal of Applied Physiology 2012 Jan;112(1):79-85

  • Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis


    Paroni G, Seripa D, Panza F, Addante F, Copetti M, D'Onofrio G, Pellegrini F, Fontana L, Pilotto A
    Age (Dordr) 2012 Aug;34(4):949-68

  • Sexually dimorphic effect of aging on skeletal muscle protein synthesis


    Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B
    Biology of Sex Differences 2012 May 23;3(1):11

  • Caloric restriction may reverse age-related autonomic decline in humans


    Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L
    Aging Cell 2012 Aug;11(4):644-50

  • Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness


    Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO
    Aging Cell 2012 Oct;11(5):876-84

  • Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance


    Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu CC, Kunz I, Rossi Fanelli F, Patterson BW, Klein S
    Cell Metabolism 2012 Nov 7;16(5):658-64

  • [The reliability and validity of Chinese version of AD8]. (article in Chinese)


    Li T, Wang HL, Yang YH, Galvin JE, Morris JC, Yu X
    Zhonghua Nei Ke Za Zhi 2012 Oct;51(10):777-80

  • Predicting road test performance in adults with cognitive or visual impairment referred to a Veterans Affairs Medical Center driving clinic


    Niewoehner PM, Henderson RR, Dalchow J, Beardsley TL, Stern RA, Carr DB
    Journal of the American Geriatric Society 2012 Nov;60(11):2070-4

2011 Publications

  • Ginseng and ginsenoside re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes


    Reeds DN, Holloszy JO, Patterson BW, Polonsky KS, Okunade A, Klein S
    Diabetes Care Volume 34, May 2011 1071-6

  • Intermittent supplementation with rapamycin as a dietary restriction mimetic


    Longo VD, Fontana L
    Aging (Albany NY) 2011 Nov;3(11):1039-40

  • Application of AD8 questionnaire to screen very mild dementia in Taiwanese


    Yang YH, Galvin JE, Morris JC, Lai CL, Chou MC, Liu CK
    American Journal of Alzheimer’s Disease & Other Dementias 2011 Mar;26(2):134-8

  • Caloric restriction: powerful protection for the aging heart and vasculature


    Weiss EP, Fontana L
    American Journal of Physiology – Heart and Circulatory Physiology 2011 Oct;301(4):H1205-19

  • Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults


    Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B
    Obesity 2011 Feb;19(2):312-8

  • Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial


    Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
    American Journal of Clinical Nutrition 2011 Feb;93(2):402-12

  • Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women


    Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
    Clinical Science (London, England) 2011 Sep;121(6):267-78

  • Calorie restriction and prevention of age-associated chronic disease


    Omodei D, Fontana L
    FEBS Letters 2011 Jun 6;585(11):1537-42

  • Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition


    Villareal DT, Kotyk J,J Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L
    Aging Cell 2011 Feb; 10(1):96-102

  • Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans


    Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L
    Aging 2011 Apr;3(4):374-9

  • Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial


    Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG; BARI 2D Study Group
    Circulation 2011 Sep 27;124(13):1426-34

  • Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis


    Galvin JE
    Prion 2011 Jan-Mar;5(1):16-21

  • AD8-Brazil: cross-cultural validation of the ascertaining dementia interview in Portuguese


    Correia CC, Lima F, Junqueira F, Campos MS, Bastos O, Petribú K, Laks J, Galvin JE
    Journal of Alzheimer’s Disease.2011;27(1):177-85

  • Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosysthesis


    Imai S
    FEBS Lett 2011 Jun 6;585(11): 1657-62

  • Predicting road test performance in drivers with dementia


    Carr DB, Barco PP, Wallendorf MJ, Snellgrove CA, Ott BR
    Journal of the American Geriatric Society 2011 Nov;59(11):2112-7

  • Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.


    Yoshino J, Mills KF, Yoon JY and Imai S.
    Cell Metab. 2011 Oct 5;14(4):528-36.

2010 Publications

  • Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases


    Imai S, Guarente L
    Trends Pharmacol Sci 2010 May;31(5):212-20

  • Relationship of dementia screening tests with biomarkers of Alzheimer's disease


    Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC
    Brain. 2010 Nov;133(11):3290-300

  • A microRNA expression signature for cervical cancer prognosis


    Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW, Wang X
    Cancer Research 2010 Feb 15;70(4):1441-8

  • Extending healthy life span – from yeast to humans


    Fontana L, Partridge L, Longo VD
    Science 2010 Apr 16;328(5976):321-6

  • Long-term effects of calorie restriction on serum sex-hormones concentrations in men


    Cangemi R, Friedmann, AJ, Holloszy JO, Fontana L
    Aging Cell 2010 Apr;9(2):236-42

  • Calorie restriction and cancer prevention: metabolic and molecular mechanisms


    Longo VD, Fontana L
    Trends in Pharmacological Sciences 2010 Feb;31(2):89-98

  • Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production


    Fontana L, Klein S, Holloszy JO
    Age 2010 Mar;32(1):97–108

  • TRB3 function in cardiac endoplasmic reticulum stress


    Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ
    Circulation Research 2010 May 14;106(9):1516-23

  • A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis


    Imai, S
    Pharmacological Research 2010 Jul;62(1):42-7

  • Organizational support and volunteering benefits for older adults


    Tang F, Choi E, Morrow-Howell N
    The Gerontologist 2010 Oct;50(5):603-12

2009 Publications

  • Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction


    Fontana L
    Experimental Gerontology 2009 Jan-Feb;44(1-2):41-5

  • “Clocks” in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging


    Imai, S
    Biochimica et Biophysica Acta 2010 Aug;1804(8):1584-90

  • Driving retirement in older adults with dementia


    Croston J, Meuser TM, Berg-Weger M, Grant EA, Carr DB
    Topics in Geriatric Rehabilitation 2009 Apr 1;25(2): 154-62

  • The scientific basis of caloric restriction leading to longer life


    Fontana L
    Current Opinion in Gastroenterology 2009 Mar;25(2):144-50

  • Modulating human aging and age-associated diseases


    Fontana L
    Biochimca et Biophysica Acta 2009 Oct;1790 (10):1133-8

  • SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty


    Imai S
    Current Opinion in Clinical Nutrition and Metabolic Care 2009 Jul;12(4):350-6

  • Who benefits from volunteering: Variations in perceived benefits


    Morrow-Howell N, Hong SI, Tang F
    The Gerontologist 2009 Feb;49 (1):91-102

  • Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis


    Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C,Takahashi JS, Imai S, Bass J
    Science 2009 May 1;324(5927): 651-4

2008 Publications

  • MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets


    Muslin AJ
    Clinical Science (London, England) 2008 Oct;115(7):203-18

  • The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan


    Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K
    PLoS Genetics 2008 Oct;4(10): e1000230

  • The measurement and analysis of age-related changes in Caenorhabditis elegans


    Collins JJ, Huang C, Hughes S, Kornfeld K
    WormBook 2008 Jan 24:1-21

  • Reduction of overweight and eating disorder symptoms via the Internet in adolescents: A randomized controlled trial


    Doyle AC, Goldschmidt A, Huang C, Winzelberg AJ, Taylor CB, Wilfley DE
    Journal of Adolescent Health 2008 Aug;43 (2): 172-9

  • Valproic acid extends Caenorhabditis elegans lifespan


    Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K
    Aging Cell 2008 Jun;7(3):305-17

  • Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans


    Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO
    Aging Cell 2008 Oct;7(5):681-7

  • Translational approaches to addressing complex genetic pathways in colorectal cancer


    Early DS, Fontana L, Davidson NO
    Translational Research 2008 Jan;151(1):10-6

  • Calorie restriction and cardiometabolic health


    Fontana L
    European Journal of Cardiovascular Prevention and Rehabilitation 2008 Feb;15(1):3-9

  • Changes in weight and health behaviors from freshman through senior year of college


    Racette, SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH
    J Nutr Educ Behav 2008 Jan-Feb;40(1):39-42

2007 Publications

  • Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk


    Fontana L, Meyer TE, Klein S. Holloszy JO
    Rejuvenation Res 2007 Jun;10(2):225-34

  • Aging, adiposity and calorie restriction


    Fontana L, Klein S
    JAMA 2007 Mar 7;297(9):986-94

  • Evaluation of cognitive impairment in older adults: combining brief informant and performance measures


    Galvin JE, Roe CM, Morris JC
    Archives of Neurology 2007 May,64(5):718-24

  • Patient’s rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia


    Galvin JE, Roe CM, Coats MA, Morris JC
    Archives of Neurology 2007 May;64(5):725-30

  • Quantifying the usefulness of CT in evaluating seniors with abdominal pain


    Lewis LM, Klippel AP, Bavolek RA, Ross LM, Scherer TM, Banet GA
    European Journal of Radiology 2007 Feb;61(2):290-6

  • Productive engagement and late life physical and mental health: Findings from a nationally representative panel study


    Hinterlong JE, Morrow-Howell N, Rozario PA
    Research on Aging 2007 Jul;29(4):348-70

2006 Publications

  • Effects of anticonvulsant drugs on life span


    Kornfeld K, Evason K
    Archives of Neurology 2006 Apr;63(4):491-6

  • Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans


    Collins JJ, Evason K, Kornfeld K
    Experimental Gerontology 2006 Oct;41(10):1032-9

  • Validity and reliability of the AD8 informant interview in dementia


    Galvin JE, Roe CM, Xiong C, Morris JC
    Neurology 2006 Dec 12;67(11):1942-8

  • Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults


    Villareal DT, Miller BV III, Banks M, Fontana L, Sinacore DR, Klein S
    The American Journal of Clinical Nutrition 2006 Dec;84(6):1317–23

2005 Publications

  • Anticonvulsant medications extend worm life-span


    Evason K, Huang C, Yamben I, Covey DF, Kornfeld K
    Science 2005 Jan 14;307(5707):258-62

  • The AD8: a brief informant interview to detect dementia


    Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M, Morris JC
    Neurology 2005 Aug 23;65(4):559-64

  • Obesity in older adults: Technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society


    Villareal DT, Apovian CM, Kushner RF, Klein S
    Obesity Research 2005 Nov;13(11):1849-63

2003 Publications

  • Effects of volunteering on the well-being of older adults


    Morrow-Howell N, Hinterlong J, Rozario PA, Tang F
    The Journal of Gerontology Series B, Psychological Sciences and Social Sciences. 2003 May;58(3):S137-45

  • Predictors of mortality in younger and older patients with heart failure and preserved or reduced left ventricular ejection fraction


    Kerzner R, Gage BF, Freedland KE, Rich MW
    American Heart Journal 2003 Aug;146(2):286-90

  • Identifying factors associated with disability-related differences in breast cancer screening (United States)


    Schootman M, Jeffe DB
    Cancer Causes and Control 2003 Mar;14(2):97-107