Laura McPherson, DPT, Ph.D. 

ABSTRACT

This study validates voluntary motor commands (VMCs) at the spinal motoneuron level as a biomarker for MS progression. Using HDsEMG and motor unit decomposition, the project tracks VMC changes over time and correlates them with clinical outcomes. Preliminary data show strong associations with strength and walk speed. The biomarker could enable earlier detection and personalized neuroplasticity therapies. NIH and DoD funding applications are planned.

Lay Summary: 
Multiple Sclerosis (MS) is a common, progressive neurodegenerative disease that affects nearly all major bodily systems and is the leading non-traumatic disabling neurological condition in young adults. While relapses in MS are easily detectable and treatable with disease-modifying drugs, the gradual progression of symptoms is harder to identify and monitor. This progression leads to accumulating disability and is often diagnosed only after irreversible damage has occurred.

This proposal introduces a novel approach to detect and monitor MS progression using voluntary motor commands (VMC) at the level of spinal motoneurons. By decoding nerve signals transmitted to muscles, researchers can assess how the central nervous system controls movement. Preliminary data suggest that changes in VMC parameters over time are greater in patients with progressing MS than in those with stable MS. The study will continue longitudinal assessments to validate VMC as a sensitive biomarker for disease progression. If successful, this method could enable earlier intervention, improve treatment decisions, and support personalized rehabilitation strategies to prevent disability in MS