Publications
Investigations funded by the Longer Life Foundation have resulted in 175 articles to date in peer-reviewed medical journals. Find them here.
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Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People With Metabolically Abnormal Obesity.
Mittendorfer B., PhD, et al. Diabetes. 2024 Aug 1; 73(8):1266-1277.
Editorial: Mitochondrial Calcium Flux-Friend or Foe in Chronic Heart Failure?
Niemi, N., PhD, et al. JACC Basic Transl Sci. 2024 Apr 22; 9(4):519-521.
The Cardiac Amyloidosis Registry Study (CARS): Rationale, Design, and Methodology.
Mitchell J, et al. May 2024, J Card Fail
Gut microbiome correlates of recurrent urinary tract infection: a longitudinal, multi-center study.
Kwon J, et al. E Clinical Medicine. 2024 Apr 26; 71: 102490
Gut microbiome composition may be an indicator of preclinical Alzheimer’s disease.
Dantas G, et al. Jun 2023, SciTransl Med.
Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy
Javaheri A, et al. Med. Dec, 2023; 4(12)
The Cardiac Amyloidosis Registry Study (CARS): Rationale, design and methodology
Khouri MG, et al. Oct 2023, Journal of Cardiac Failure
Heterogeneity in the effect of marked weight loss on metabolic function in women with obesity
Mittendorfer B, et al. JCI Insight. May 9, 2023; 8(12)
Intravenous ravulizumab in mechanically ventilated patients hospitalised with severe COVID-19: a phase 3, multicentre, open-label, randomised controlled trial
Annane D, et al. Lancet Respiratory Medicine. 2023 Dec; 11(12): 1051-1063
Implementing a Machine-Learning-Adapted Algorithm to Identify Possible Transthyretin Amyloid Cardiomyopathy at an Academic Medical Center
Mitchell J, et al. Nov 2022, Clin Med Insights Cardiol
Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
Zhang et al., 2022, Cell Reports Medicine 3, 100498
Insulin, Nobel laureates and The Journal of Physiology
Bettina Mittendorfer, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA, J Physiol 0.0 (2022) pp 1–2, 2022
Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21
Christine R. Zhang, Grant A. Challen, et al; Blood Cancer Discovery, AACRJournals.org, Published online May, 2022.
Persisting uropathogenic Escherichia coli lineages show signatures of niche-specific within-host adaptation mediated by mobile genetic elements
Thanert et al., 2022, Cell Host & Microbe 30, 1–14 July 13, 2022 ª 2022 Elsevier Inc.
Evaluating the therapeutic potential of ADAR1 inhibition for triple-negative breast cancer
Che-Pei Kung 1, Kyle A. Cottrell1, Sua Ryu1, Emily R. Bramel1, Raleigh D. Kladney1, Emily A. Bao1, Eric C. Freeman1, Thwisha Sabloak1, Leonard Maggi Jr.1, Jason D. Weber 1,2: Oncogene
https://doi.org/10.1038/s41388-020-01515-5
PARROT: a flexible recurrent neural network framework for analysis of large protein datasets
Daniel Griffith1,2, Alex S. Holehouse1,2* 1. bioRxiv, Cold Spring Harbor Laboratory.
Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease
Anja Fuchs,1 Dmitri Samovski,2 Gordon I. Smith,2 Vincenza Cifarelli,2Sarah S. Farabi,2 Jun Yoshino,2 Terri Pietka,2 Shin-Wen Chang,1 Sarbani Ghosh,1 Terence M. Myckatyn,1 and Samuel Klein2
Gastroenterology 2021;161:968–981
The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
Cubuk J, Alston JJ, Incicco JJ, Singh S, Stuchell-Brereton MD, Ward MD, Zimmerman MI, Vithani N, Griffith D, Wagoner JA, Bowman GR, Hall KB, Soranno A, Holehouse AS., Nat Comun, 2021.
Preeclampsia Predicts Risk of Hospitalization for Heart Failure With Preserved Ejection Fraction
Dominique Williams, MD,a Molly J. Stout, MD, MSCI,b Joshua I. Rosenbloom, MD, MPH,c Margaret A. Olsen, PHD, MPH,d Karen E. Joynt Maddox, MD, MPH,a Elena Deych, MS,a Victor G. Davila-Roman, MD,a Kathryn J. Lindley, MDa,c Journal of the American College of Cardiology. Published online 2021. Vol. 78, No. 23.
Beta-cell function and plasma insulin clearance in people with obesity and different glycemic status
Bettina Mittendorfer, … , Mihoko Yoshino, Samuel Klein: J Clin Invest. 2021.
Microbiome Restoration by RBX2660 Does Not Preclude Recurrence of Multidrug-Resistant Urinary Tract Infection Following Subsequent Antibiotic Exposure: A Case Report
Eric C. Keen, Preston Tasoff, Tiffany Hink, Kimberly A. Reske, Carey-Ann D. Burnham, Gautam Dantas, Jennie H. Kwon, and Erik R. Dubberke; CDC Prevention Epicenters Program, Open Forum Infectious Diseases
Amended: High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy
Xiangyu Zhang, Ismail Sergin, Trent D. Evans, Se-Jin Jeong, Astrid Rodriguez-Velez, Divya Kapoor, Sunny Chen, Eric Song, Karyn B. Holloway, Jan R. Crowley, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Bettina Mittendorfer, Nathan O. Stitziel, Joel D. Schilling, Irfan J. Lodhi, Babak Razani; Nat Metab. 2020 January ; 2(1): 110–125. doi:10.1038/s42255-019-0162-4.
Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
Elizabeth L. Ostrander, Ashley C. Kramer, Cates Mallaney, Hamza Celik, Won Kyun Koh, Jake Fairchild, Emily Haussler, Christine R.C. Zhang, and Grant A. Challen;
Stem Cell Reports. April 14, 2020; Vol. 14: 551–560.
Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice
Yiming Zhang, Nurmohammad Shaikh, Jeremie L. Ferey, Umesh D. Wankhade, Sree V. Chintapalli, Cassandra B. Higgins, Jan R. Crowley, Monique R. Heitmeier, Alicyn I. Stothard, Belgacem Mihi, Misty Good, Takanobu Higashiyama, Benjamin M. Swarts, Paul W. Hruz, Kartik Shankar, Phillip I. Tarr, and Brian J. DeBosch; Gastroenterology 2020, Vol. 158, No. 5;158:1402–1416
What are protective antibody responses to pandemic SARS-CoV-2?
Jeffrey P. Henderson; J Clin Invest. 2020;130(12):6232–6234. Published in Volume 130, Issue 12, Dec. 1, 2020.
Association of Convalescent Plasma Therapy With Survival in Patients With Hematologic Cancers and COVID-19
Michael A. Thompson, MD, PhD1; Jeffrey P. Henderson, MD, PhD2; Pankil K. Shah, MD, MSPH3; et al JAMA Oncol. Published online June 17, 2021. doi:10.1001/jamaoncol.2021.1799.
Dietary protein intake and obesity-associated cardiometabolic function
Alan Fappi 1, Bettina Mittendorfer; Curr Opin Clin Nutr Metab Care . 2020 Nov;23(6):380-386. doi: 10.1097/MCO.0000000000000689.
High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy
Xiangyu Zhang, Ismail Sergin, Trent D. Evans, Se-Jin Jeong, Astrid Rodriguez-Velez, Divya Kapoor, Sunny Chen, Eric Song, Karyn B. Holloway, Jan R. Crowley, Slava Epelman, Conrad C. Weihl, Abhinav Diwan, Daping Fan, Bettina Mittendorfer, Nathan O. Stitziel, Joel D. Schilling, Irfan J. Lodhi & Babak Razani Nature Metabolism . 23 January 2020. Volume 2, pages 110–125 (2020)
Young versus old age at diagnosis confers distinct genomic profiles in patients with polycythemia vera
Fowles JS,1 How J,1 Allen MJ,1 Oh ST.1 Leukemia (2019) 33:1522–1526
Comparative Genomics of Antibiotic-Resistant Uropathogens Implicates Three Routes for Recurrence of Urinary Tract Infections
Thänert R, Reske KA, Hink T, Wallace TA, Wang B, Schwartz DJ, Seiler S, Cass C, Burnham CD, Dubberke ER, Kwon JH, Dantas G, for the CDC Prevention Epicenter Program Clinical Science and Epidemiology (2019) e01977-19
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L. Cell Metabolism. 2018 Jun 5; 27(6): 1222-35.
Higher Body Mass Index Is Associated with Lower Cortical Amyloid-β Burden in Cognitively Normal Individuals in Late-Life
Vineeth Thirunavu, Austin McCullough, Yi Suc, Shaney Flores, Aylin Dincer, John C. Morris, Carlos Cruchaga, Tammie L.S. Benzinger, Brian A. Gordon; J Alzheimers Dis. 2019 ; 69(3): 817–827. doi:10.3233/JAD-190154.
Maximal dose-response of vitamin-K2 (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis
Tusar K Giri1, David Newton, Opal Chaudhary, Elena Deych, Nicola Napoli, Reina Armamento-Villareal1, Kathy Diemer, Paul E Milligan, and Brian F Gage; Int J Vitam Nutr Res (2019), 1–7
Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita
Wilson Chun Fok, Siddharth Shukla, Alexandre Teixeira Vessoni, Kirsten Ann Brenner, Roy Parker, Christopher M. Sturgeon, and Luis Francisco Zirnberger Batista; Blood Journal: The American Society of Hematology. 21 March 2019, Vol. 133, No. 12
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti V, Bertozzi B, Fontana L. Journal of Gerontology: Biological Sciences. 2018 Mar 2; 73(3):318-26.
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
Fontana L, Mitchell SE, Wang B, Tosti V, van Vliet T, Veronese N, Bertozzi B, Early DS, Maissan P, Speakman JR, Demaria M. Aging Cell 2018 Jun; 17(3): e12746.
Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota
Cignarella F, Cantoni C, Ghezzi L, Salter A, Dorsett Y, Chen L, Phillips D, Weinstock GM, Fontana L, Cross AH, Zhou Y, Piccio L. Cell Metabolism. 2018 Jun 5; 27(6): 1222-35.
Interventions to promote cardiometabolic health and slow cardiovascular ageing
Fontana L. Nature Reviews Cardiology. 2018 Sep; 15(9): 566-77.
Calorie restriction induces reversible lymphopenia and lymphoid organ atrophy due to cell redistribution
Contreras NA, Fontana L, Tosti V, Nikolich-Žugich J. Geroscience. 2018 Jun; 40(3): 279-91.
Low-protein diet in cancer: ready for prime time?
Pili R, Fontana L. Nature Reviews Endocrinology. 2018 May 15; 14(7): 384-6.
Caloric Restriction and Cellular Senescence: Mechanisms of Ageing and Development
Fontana L, Nehme J, Demaria M.
Mechanisms of Ageing and Development. 2018 Dec; 176: 19-23.
Sarcosine is Uniquely Modulated by Aging and Dietary Restriction in Rodents and Humans
Walters RO, Arias E, Diaz A, Burgos ES, Guan F, Tiano S, Mao K, Green CL, Qiu Y, Shah H, Wang D, Hudgins AD, Tabrizian T, Tosti V, Shechter D, Fontana L, Kurland IJ, Barzilai N, Cuervo AM, Promislow DEL, Huffman DM.
Cell Reports. 2018 Oct 16; 25(3): 663-76.
Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms
Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR.
JCI Insight. 2018 Nov 2; 3(21).
Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis
Wardill HR, Van Sebille YZA, Ciorba MA, Bowen JM.
Curr Opin Support Palliat Care. 2018 Mar 14.
Regulation of Insulin Receptor Pathway and Glucose Metabolism by CD36 Signaling
Dmitri Samovski, Pallavi Dhule, Terri Pietka, Miriam Jacome-Sosa, Eric Penrose, Ni-Huiping Son, Robert C. Flynn, Kooresh I. Shoghi, Krzysztof L. Hyrc, Ira J. Goldberg, Eric R. Gamazon and Nada A. Abumrad
Diabetes 2018 May; db171226. https://doi.org/10.2337/db17-1226
Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy
Orillion A, Damayanti NP, Shen L, Adelaiye-Ogala R, Affronti H, Elbanna M, Chintala S, Ciesielski M, Fontana L, Kao C, Elzey BD, Ratliff TL, Nelson DE, Smiraglia D, Abrams SI, Pili R.
Clinical Cancer Research. 2018 Dec 15; 24(24): 6383-95.
Trends in Age-Related Disease Burden and Healthcare Utilization
Atella V, Piano-Mortari A, Kopinska J, Belotti F, Lapi F, Cricelli C, Fontana L.
Aging Cell 2018; 18(1): e12861.
Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation
Jonathan R Brestoff, Alexandre T Vessoni, Kirsten A Brenner,
Geoffrey L Uy, John F DiPersio, Morey Blinder, Chad A Witt, Derek E Byers, Ramsey R Hachem, Elbert P Truclock, Dayna S Early, Milan J Anadkat, Amy Musiek, Cylen Javidan-Nejad, Dennis M Balfe, Ilana S Rosman, Chang Liu, Lingxin Zhang, George J Despotis, Marianna B Ruzinova, Jennifer K Sehn,Ina Amarillo, Jonathan W Heusel, Wojcieh Swat, Brian S Kim, Lukas D Wartman, Roger D Yusen, Luis F Z Batista; Thorax 2018;73:489–492. doi:10.1136/thoraxjnl-2017-211121.
The science of nutritional modulation of aging
Fontana L.
Ageing Research Reviews. 2017 Oct; 39: 1-2.
Perspective: Improving Nutritional Guidelines for Sustainable Health Policies: Current Status and Perspectives
Magni P, Bier DM, Pecorelli S, Agostoni C, Astrup A, Brighenti F, Cook R, Folco E, Fontana L, Gibson RA, Guerra R, Guyatt GH, Ioannidis JP, Jackson AS, Klurfeld DM, Makrides M, Mathioudakis B, Monaco A, Patel CJ, Racagni G, Schünemann HJ, Shamir R, Zmora N, Peracino A.
Advances in Nutrition. 2017 Jul 14; 8(4): 532-45.
In a Randomized Trial in Prostate Cancer Patients, Dietary Protein Restriction Modifies Markers of Leptin and Insulin Signaling in Plasma Extracellular Vesicles
Eitan E, Tosti V, Suire CN, Cava E, Berkowitz S, Bertozzi B, Raefsky SM, Veronese N, Spangler R, Spelta F, Mustapic M, Kapogiannis D, Mattson MP, Fontana L.
Aging Cell. 2017 Dec; 16(6): 1430-3.
Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being. Gerontology
Bertozzi B, Tosti V, Fontana L.
Gerontology. 2017; 63(1): 13-9. (Epub 2016 May 14.)
Alterations in 3-Hydroxyisobutyrate and FGF21 Metabolism are Associated with Protein Ingestion-Induced Insulin Resistance
Harris LLS, Smith GI, Patterson BW, Ramaswamy RS, Okunade A, Kelly SC, Porter LC, Klein S, Yoshino J, Mittendorfer B:
Diabetes 2017 (PMID: 28473464)
Dietary protein, aging and nutritional geometry
Simpson SJ, Le Couteur DG, Raubenheimer D, Solon Biet SM, Cooney GJ, Cogger VC, Fontana L.
Aging Research Reviews. 2017 Oct; 39:78-86.
Calorie Restriction in Humans: An Update
Most J, Tosti V, Redman LM, Fonana L.
Aging Research Reviews 2017 Oct; 39: 36-45. (Epub 2016 Aug 17.)
Renal and Systemic Effects of Calorie Restriction in Type 2 Diabetes With Abdominal Obesity: A Randomized Controlled Trial
Ruggenenti P, Abbate M, Ruggiero B, Rota S, Trillini M, Aparicio C, Parvanova A, Iliev IP, Pisanu G, Perna A, Russo A, Diadei O, Martinetti D, Cannata A, Carrara F, Ferrari S, Stucchi N, Remuzzi G, Fontana L.
Diabetes. 2017 Jan; 66(1): 75-86. (Epub 2016 Sep 15.).
Gnotobiotic Mouse Models for Identifying Consistent Effects of Different Nutritional Lifestyles on the Gut Microbiota of Multiple Unrelated Humans
Griffin NW, Ahern PP, Cheng J, Heath AC, Fontana L, Gordon JI.
Cell Host and Microbe. 2017: 21(1): 84-96.
A Simple Culture System for Long-Term Imaging of Individual C. Elegans
Pittman WE, Sinha DB, Zhang WB, Kinser HE & Pincus Z.
Lab Chip. 2017; 77, 71 (2017). (open access available 2018-11-07.)
Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice
Lamming DW, Baar EL, Arriola Apelo SI, Tosti V, Fontana L.
Nutrition and Healthy Aging. 2017 Dec 7; 4(3):239-45.
Successful Completion of the Pilot Phase of a Randomized Controlled Trial Comparing Sentinel Lymph Node Biopsy to No Further Axillary Staging in Patients with Clinical T1-T2 N0 Breast Cancer and Normal Axillary Ultrasound
Cyr AE, Tucker N, Ademuyiwa F et al. J Am Coll Surg.2016 Aug;223(2):399-407.
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36
Love-Gregory L, Kraia AT, Allum F et al. J Lipid Res. 2016 Dec57(12):2176-84.
Extended Twilight among Isogenic C. elegans Causes a Disproportionate Scaling between Lifespan and Health
Zhang WB, Sinha DB, Pittman WE, Hvatum E, Stroustrup N, Pincus Z.
Cell Systems, 2016 Oct 26;3(4):333-45.
NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice
Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J. Cell Reports. 2016 Aug 16;16(7):1851-60.
Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future “Non-Cognitive” Outcomes of Alzheimer’s Disease
Ingber AP, Hassenstab J, Fagan AM, Benzinger TL, Grant EA, Holtzman DM, Morris JC, Roe CM. J Alzheimers Dis. 2016;52(3):1055-64.
Human Metabolome-Derived Cofactors are Required for the Antibacterial Activity of Siderocalin in Urine
Shields-Cutler RR, Crowley JR, Miller CD, Stapleton AE, Cui W, Henderson JP.
The Journal of Biological Chemistry. 2016 Oct. 25.
Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle
Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Cell Reports. 2016 Jan 26;14(3):422-8.
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health
Fontana L, Cummings NE, Arriola Apelo SI et al. Cell Reports, 2016 Jul 12;16(2):520-30.
Calorie restriction in humans: An update
Most J, Tosti V, Redman LM, Fontana L.
Ageing Res Rev., 2016 Aug 17.
High-protein intake during weight-loss therapy eliminates the weight loss-induced improvement in insulin action in obese postmenopausal women
Smith GI, Yoshino J, Kelly SC, Reeds DN, Okunade A, Patterson BW, Klein S, Mittendorfer B. Cell Reports. Oct. 11, 2016.
Predicting all-cause mortality from basic physiology in the Framingham Heart Study
Zhang WB, Pincus Z. Aging Cell, 2016 Feb 15. (1):39-48.
Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity
Magkos F, Fraterrigo G, Yoshino J, Luecking C, Kirbach K, Kelly SC, de Las Fuentes L, He S, Okunade AL, Patterson BW, Klein S.
Cell Metabolism, 2016 Feb 22. pii: S1550-4131(16)30053-5. doi: 10.1016/j.cmet.2016.02.005. [Epub ahead of print]
Probiotic Gut Bacteria Enhance Cancer Immunotherapy in a Mouse Model of Melanoma
Dey N, Ciorba MA.
Gastroenterology. 2016 May 26. pii: S0016-5085(16)34458-4. doi: 10.1053/j.gastro.2016.05.015. [Epub ahead of print] No abstract available.
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, …, Koji Uchida,
Jun Yoshino, Shin-ichiro Imai
Cell Metabolism, December 13, 2016 , 24, 1–12 [Epub ahead of print]
Combined associations of body weight and lifestyle factors with all-cause and cause-sepcific mortality in men and women: prospective cohort study
Veronese N, Li Y, Manson JE, Willett WC, Fonana L, Hu FB.
BMJ 2016 Nov. 24; 355.
Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss
Su X, Magkos F, Zhou D, Eagon JC, Fabbrini E, Okunade AL, Klein S.
Obesity, 2015 Feb; 23(2):329-34
Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer
Morrissey JJ, Mobley J, Figenshau RS, Vetter J, Bhayani S, Kharasch ED
Mayo Clinic Proceedings, 2015 Jan; 90(1):35-42
Human urinary composition controls antibacterial activity of siderocalin
Shields-Cutler RR, Crowley JR, Hung CS, Stapleton AE, Aldrich CC, Marschall J, Henderson JP
The Journal of Biological Chemistry, 2015 April 10
Promoting health and longevity through diet: from model organisms to humans
Fontana L, Partridge L
Cell, 2015 March 25; 161(1); 106-18
Calorie restriction, endothelial function and b¬lood pressure homeostasis
Spelta F, Bertozzi B, Cominacini L, Fontana L
Vascul Pharmacol, 2015 Feb-Mar, 65-6:1-2.
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Levine M, Suarez J, Brandhorst S, Balasubramanian, Cheng CW, Madia F, Fontana L, Mirisola MP, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins E, Longo VD
Cell Metabolism 2014 Mar 4;19(3):407–17
Probiotics to prevent gastrointestinal toxicity from cancer therapy: an interpretive review and call to action
Ciorba MA, Hallemeier CL, Stenson WF, Parikh PJ.
Curr Opin Support Palliat Care. 2015 Jun;9(2):157-62. doi: 10.1097/SPC.0000000000000134. Review.
PMID: 25872116
Network Analysis Reveals Sex- and Antibiotic Resistance-Associated Antivirulence Targets in Clinical Uropathogens
Parker KS, Wilson JD, Marschall J, Mucha PJ, Henderson JP.
ACS Infect Dis. 2015 Nov 13;1(11):523-32.
“Noncognitive” symptoms of early Alzheimer disease: a longitudinal analysis
Masters MC, Morris JC, Roe CM.
Neurology. 2015 Feb. 10; 84(6): 617-22.
Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model
Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L. Oncotarget. 2015 Oct 13; 6(31): 31233-40.
Interventions to Slow Aging in Humans: Are We Ready?
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.
Aging Cell. 2015 Apr 22; 14(4):497-510.
Energy requirements in nonobese men and women: results from CALERIE
Redman LM, Kraus WE, Bhapkar M, Das SK, Racette SB, Martin CK, Fontana L, Wong WW, Robert SB, Ravussin E, for the CALERIE Study Group
Am J Clin Nutr Jan 2014
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P; Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo, VD
Cell Metabolism 19, 407-17, March 4, 2014
Optimal body weight for health and longevity: bridging basic, clinical, and population research
Fontana L, Hu FB
Aging Cell (2014) pp 1-10
Postprandial plasma incretin hormones in exercise-trained versus untrained subjects
Weiss EP, Royer NK, Fisher JS, Holloszy JO, Fontana L
Med Sci Sports Exerc 2014 Jun; 46(6): 1098-103
Cytochrome P450 gene variants, race and mortality among clopidogrel-treated patients after acute myocardial infarction
Cresci S, Depta JP, Lenzini PA, Li AY, Lanfear DE, Province MA, Spertus JA,. Bach RG
Circ Cardiovasc Genet 2014 Jun;7(3):277-86
Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade
Morrissey JJ, Mobley J, Song J, Vetter J, Luo J, Bhayani S, Figenshau RS , Kharasch ED
Urology 2014 Jan;83(1): 256
Activation of miR-9 by human papillomavirus in cervical cancer
Liu W, Gao g,, Hu X, Wang Y, Schwarz JK, Chen JJ, Grigsby PW, Wang X
Oncotarget, 2014 Nov 30; 5(22):11620-30
CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction
Chen LS, Bach RG, Lenzini PA, Spertus JA, Bierut LJ, Cresci S
Nicotine Tob Res 2014 Sep;16(9):1224-31
What are the roles of calorie restriction and diet quality in promoting healthy longevity?
Rizza W, Veronese N, Fontana L
Ageing Research Reviews 2014 Jan; 13:38-45
Medical research: treat ageing
Fontana L, Kennedy BK, Longo VD, Seals D, Melov S
Nature 2014 Jul 24;511(7510):405-7
Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later
Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D; Sutphen CL, Benzinger TL, Mintun MA, Holtzman DM, Morris JC
Neurology 2013 May 7;80(19):1784-91
The specificity of urinary aquaporin 1 and perilipin 2 to screen for renal cell carcinoma
Morrissey JJ, Kharasch ED
The Journal of Urology, 2013 May; 189(5):1913-20
Assessing the diagnostic accuracy (DA) of the Spanish version of the informant-based AD8 questionnaire
Carnero Pardo C, de la Vega Cotarelo R, López Alcalde S, Martos Aparicio C, Vilchez Carrillo R, Mora Gavilán E, Galvin JE
Neurologia 2013 Mar;28(2):88-94
“Deficiency” of mitochondria in muscle does not cause insulin resistance
Holloszy JO
Diabetes 2013 Apr;62 (4): 1036-40
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L
Aging Cell 2013 Aug;12(4):645-51
Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer’s disease mouse model
Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD
Aging Cell 2013 Apr;12(2):257-68
Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalized older patients
Fontana L, Addante F, Copetti M, Paroni G, Fontana A, Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A
Aging Cell 2013 Jun;12(3):459-66
Will calorie restriction work in humans?
Cava E, Fontana L
Aging 2013 Jul;5(7):507-14
Serum from humans on long-term calorie restriction enhances stress resistance in cell culture
Omodei D, Licastro D, Salvatore F, Crosby SD, Fontana L
Aging 2013 Aug;5(8):599-606
Energy efficiency as a unifying principle for human, environmental, and global health
Fontana L, Atella V, Kammen DM
F1000Research 2013, 2:101
Multiple dietary supplements do not affect metabolic and cardiovascular health
Soare A, Weiss EP, Holloszy JO, Fontana L
Aging 2013 Sep 4 (Epub)
Dietary protein restriction inhibits tumor growth in human xenograft models
Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R
Oncotarget 2013 Dec;4(12):2451-61
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S
Gastroenterology 2013 Aug;145(2):366-74
CSF biomarkers of Alzheimer disease: “noncognitive” outcomes
Roe CM, Fagan AM, Grant EA, Holtzman DM, Morris JC
Neurology 2013 Dec 3;81(23):2028-31
Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography
Yoshino J, Imai S
Methods Mol Biol 2013;1077:203-15
An exploration of salivation patterns in normal weight and obese children
Aspen VA, Stein RI, Wilfley DE
Appetite 2012 Apr 58(2):539-42
Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults
Villareal DT, Smith GI, Shah K, Mittendorfer B
Obesity 2012 Sep;20 (9):1780-6
Adrenergic-pathway gene variants influence beta-blocker-related outcomes after acute coronary syndrome in a race-specific manner
Cresci S, Dorn GW 2nd, Jones PG, Beitelshees, AL, Li AY, Lenzini PA, Province MA, Spertus JA, Lanfear DE
Journal of the American College of Cardiology 2012 Sep 4;60(10):898-907
Growth factors, nutrient signaling, and cardiovascular aging
Fontana L, Vinciguerra M, Longo VD
Circulation Research 2012 Apr 13;110(8):1139-50
Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss as compared to calorie restriction
Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP
Journal of Applied Physiology 2012 Jan;112(1):79-85
Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis
Paroni G, Seripa D, Panza F, Addante F, Copetti M, D’Onofrio G, Pellegrini F, Fontana L, Pilotto A
Age (Dordr) 2012 Aug;34(4):949-68
Sexually dimorphic effect of aging on skeletal muscle protein synthesis
Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B
Biology of Sex Differences 2012 May 23;3(1):11
Caloric restriction may reverse age-related autonomic decline in humans
Stein PK, Soare A, Meyer TE, Cangemi R, Holloszy JO, Fontana L
Aging Cell 2012 Aug;11(4):644-50
Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness
Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO
Aging Cell 2012 Oct;11(5):876-84
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
Yoshino J, Conte C, Fontana L, Mittendorfer B, Imai S, Schechtman KB, Gu CC, Kunz I, Rossi Fanelli F, Patterson BW, Klein S
Cell Metabolism 2012 Nov 7;16(5):658-64
[The reliability and validity of Chinese version of AD8]. (article in Chinese)
Li T, Wang HL, Yang YH, Galvin JE, Morris JC, Yu X
Zhonghua Nei Ke Za Zhi 2012 Oct;51(10):777-80
Predicting road test performance in adults with cognitive or visual impairment referred to a Veterans Affairs Medical Center driving clinic
Niewoehner PM, Henderson RR, Dalchow J, Beardsley TL, Stern RA, Carr DB
Journal of the American Geriatric Society 2012 Nov;60(11):2070-4
Ginseng and ginsenoside re do not improve ß-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes
Reeds DN, Holloszy JO, Patterson BW, Polonsky KS, Okunade A, Klein S
Diabetes Care Volume 34, May 2011 1071-6
Intermittent supplementation with rapamycin as a dietary restriction mimetic
Longo VD, Fontana L
Aging (Albany NY) 2011 Nov;3(11):1039-40
Application of AD8 questionnaire to screen very mild dementia in Taiwanese
Yang YH, Galvin JE, Morris JC, Lai CL, Chou MC, Liu CK
American Journal of Alzheimer’s Disease & Other Dementias 2011 Mar;26(2):134-8
Caloric restriction: powerful protection for the aging heart and vasculature
Weiss EP, Fontana L
American Journal of Physiology – Heart and Circulatory Physiology 2011 Oct;301(4):H1205-19
Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults
Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B
Obesity 2011 Feb;19(2):312-8
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
Smith GI, Atherton P, Reeds DN, Mohammed BS, Rankin D, Rennie MJ, Mittendorfer B
American Journal of Clinical Nutrition 2011 Feb;93(2):402-12
Calorie restriction and prevention of age-associated chronic disease
Omodei D, Fontana L
FEBS Letters 2011 Jun 6;585(11):1537-42
Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition
Villareal DT, Kotyk J,J Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L
Aging Cell 2011 Feb; 10(1):96-102
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
Yoshino J, Mills KF, Yoon JY and Imai S.
Cell Metab. 2011 Oct 5;14(4):528-36.
Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L
Aging 2011 Apr;3(4):374-9
Peroxisome proliferator-activated receptor pathway gene polymorphism associated with extent of coronary artery disease in patients with type 2 diabetes in the bypass angioplasty revascularization investigation 2 diabetes trial
Cresci S, Wu J, Province MA, Spertus JA, Steffes M, McGill JB, Alderman EL, Brooks MM, Kelsey SF, Frye RL, Bach RG; BARI 2D Study Group
Circulation 2011 Sep 27;124(13):1426-34
Dementia screening, biomarkers and protein misfolding: Implications for public health and diagnosis
Galvin JE
Prion 2011 Jan-Mar;5(1):16-21
AD8-Brazil: cross-cultural validation of the ascertaining dementia interview in Portuguese
Correia CC, Lima F, Junqueira F, Campos MS, Bastos O, Petribú K, Laks J, Galvin JE
Journal of Alzheimer’s Disease.2011;27(1):177-85
Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosysthesis
Imai S
FEBS Lett 2011 Jun 6;585(11): 1657-62
Predicting road test performance in drivers with dementia
Carr DB, Barco PP, Wallendorf MJ, Snellgrove CA, Ott BR
Journal of the American Geriatric Society 2011 Nov;59(11):2112-7
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Imai S, Guarente L
Trends Pharmacol Sci 2010 May;31(5):212-20
Relationship of dementia screening tests with biomarkers of Alzheimer’s disease
Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC
Brain. 2010 Nov;133(11):3290-300
A microRNA expression signature for cervical cancer prognosis
Hu X, Schwarz JK, Lewis JS Jr, Huettner PC, Rader JS, Deasy JO, Grigsby PW, Wang X
Cancer Research 2010 Feb 15;70(4):1441-8
Extending healthy life span – from yeast to humans
Fontana L, Partridge L, Longo VD
Science 2010 Apr 16;328(5976):321-6
Long-term effects of calorie restriction on serum sex-hormone concentrations in men
Cangemi R, Friedmann, AJ, Holloszy JO, Fontana L
Aging Cell 2010 Apr;9(2):236-42
Calorie restriction and cancer prevention: metabolic and molecular mechanisms
Longo VD, Fontana L
Trends in Pharmacological Sciences 2010 Feb;31(2):89-98
Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
Fontana L, Klein S, Holloszy JO
Age 2010 Mar;32(1):97–108
TRB3 function in cardiac endoplasmic reticulum stress
Avery J, Etzion S, DeBosch BJ, Jin X, Lupu TS, Beitinjaneh B, Grand J, Kovacs A, Sambandam N, Muslin AJ
Circulation Research 2010 May 14;106(9):1516-23
A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis
Imai, S
Pharmacological Research 2010 Jul;62(1):42-7
Organizational support and volunteering benefits for older adults
Tang F, Choi E, Morrow-Howell N
The Gerontologist 2010 Oct;50(5):603-12
Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction
Fontana L
Experimental Gerontology 2009 Jan-Feb;44(1-2):41-5
“Clocks” in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging
Imai, S
Biochimica et Biophysica Acta 2010 Aug;1804(8):1584-90
Driving retirement in older adults with dementia
Croston J, Meuser TM, Berg-Weger M, Grant EA, Carr DB
Topics in Geriatric Rehabilitation 2009 Apr 1;25(2): 154-62
The scientific basis of caloric restriction leading to longer life
Fontana L
Current Opinion in Gastroenterology 2009 Mar;25(2):144-50
Modulating human aging and age-associated diseases
Fontana L
Biochimca et Biophysica Acta 2009 Oct;1790 (10):1133-8
SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
Imai S
Current Opinion in Clinical Nutrition and Metabolic Care 2009 Jul;12(4):350-6
Who benefits from volunteering: Variations in perceived benefits
Morrow-Howell N, Hong SI, Tang F
The Gerontologist 2009 Feb;49 (1):91-102
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C,Takahashi JS, Imai S, Bass J
Science 2009 May 1;324(5927): 651-4
MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
Muslin AJ
Clinical Science (London, England) 2008 Oct;115(7):203-18
The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan
Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K
PLoS Genetics 2008 Oct;4(10): e1000230
The measurement and analysis of age-related changes in Caenorhabditis elegans
Collins JJ, Huang C, Hughes S, Kornfeld K
WormBook 2008 Jan 24:1-21
Reduction of overweight and eating disorder symptoms via the Internet in adolescents: A randomized controlled trial
Doyle AC, Goldschmidt A, Huang C, Winzelberg AJ, Taylor CB, Wilfley DE
Journal of Adolescent Health 2008 Aug;43 (2): 172-9
Valproic acid extends Caenorhabditis elegans lifespan
Evason K, Collins JJ, Huang C, Hughes S, Kornfeld K
Aging Cell 2008 Jun;7(3):305-17
Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO
Aging Cell 2008 Oct;7(5):681-7
Translational approaches to addressing complex genetic pathways in colorectal cancer
Early DS, Fontana L, Davidson NO
Translational Research 2008 Jan;151(1):10-6
Calorie restriction and cardiometabolic health
Fontana L
European Journal of Cardiovascular Prevention and Rehabilitation 2008 Feb;15(1):3-9
Changes in weight and health behaviors from freshman through senior year of college
Racette, SB, Deusinger SS, Strube MJ, Highstein GR, Deusinger RH
J Nutr Educ Behav 2008 Jan-Feb;40(1):39-42
Long-term low-calorie low-protein vegan diet and endurance exercise are associated with low cardiometabolic risk
Fontana L, Meyer TE, Klein S. Holloszy JO
Rejuvenation Res 2007 Jun;10(2):225-34
Aging, adiposity and calorie restriction
Fontana L, Klein S
JAMA 2007 Mar 7;297(9):986-94
Evaluation of cognitive impairment in older adults: combining brief informant and performance measures
Galvin JE, Roe CM, Morris JC
Archives of Neurology 2007 May,64(5):718-24
Patient’s rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia
Galvin JE, Roe CM, Coats MA, Morris JC
Archives of Neurology 2007 May;64(5):725-30
Quantifying the usefulness of CT in evaluating seniors with abdominal pain
Lewis LM, Klippel AP, Bavolek RA, Ross LM, Scherer TM, Banet GA
European Journal of Radiology 2007 Feb;61(2):290-6
Productive engagement and late life physical and mental health: Findings from a nationally representative panel study
Hinterlong JE, Morrow-Howell N, Rozario PA
Research on Aging 2007 Jul;29(4):348-70
Effects of anticonvulsant drugs on life span
Kornfeld K, Evason K
Archives of Neurology 2006 Apr;63(4):491-6
Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans
Collins JJ, Evason K, Kornfeld K
Experimental Gerontology 2006 Oct;41(10):1032-9
Validity and reliability of the AD8 informant interview in dementia
Galvin JE, Roe CM, Xiong C, Morris JC
Neurology 2006 Dec 12;67(11):1942-8
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults
Villareal DT, Miller BV III, Banks M, Fontana L, Sinacore DR, Klein S
The American Journal of Clinical Nutrition 2006 Dec;84(6):1317–23
Anticonvulsant medications extend worm life-span
Evason K, Huang C, Yamben I, Covey DF, Kornfeld K
Science 2005 Jan 14;307(5707):258-62
The AD8: a brief informant interview to detect dementia
Galvin JE, Roe CM, Powlishta KK, Coats MA, Muich SJ, Grant E, Miller JP, Storandt M, Morris JC
Neurology 2005 Aug 23;65(4):559-64
Obesity in older adults: Technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society
Villareal DT, Apovian CM, Kushner RF, Klein S
Obesity Research 2005 Nov;13(11):1849-63
Effects of volunteering on the well-being of older adults
Morrow-Howell N, Hinterlong J, Rozario PA, Tang F
The Journal of Gerontology Series B, Psychological Sciences and Social Sciences. 2003 May;58(3):S137-45
Predictors of mortality in younger and older patients with heart failure and preserved or reduced left ventricular ejection fraction
Kerzner R, Gage BF, Freedland KE, Rich MW
American Heart Journal 2003 Aug;146(2):286-90
Identifying factors associated with disability-related differences in breast cancer screening (United States)
Schootman M, Jeffe DB
Cancer Causes and Control 2003 Mar;14(2):97-107
