Long-Term Benefits of Caloric Restriction: Does Intermittent snoRNAs and Long-Term Risk of Diabetic Complications

Jean E. Schaffer, M.D.

Project Overview
We have recently discovered that small RNA molecules that do not encode proteins can function as critical mediators of oxidant stress in the setting of high levels of metabolites. We hypothesize that genetic variation in these RNA molecules underlies differences in susceptibility to diabetic complications.

We will sequence the DNA regions that encode these small RNAs in people with diabetes who have a range of complications. Our goal is to determine whether variation(s) in these sequences is related to development of complications. Knowledge obtained from this work could be used in the future to predict diabetic complications and to develop novel therapies.