Identification of Novel Blood Biomarkers and Mediators of Obesity-induced Insulin Resistance

Jun Yoshino, M.D., Ph.D.

Project Overview:
Obesity-induced insulin resistance is an important risk factor of various age-associated chronic diseases, such as type 2 diabetes, cardiovascular disease and cancer, and it is emerging as a major public health problem in our aging society. Therefore, an accurate, simple and inexpensive blood biomarker(s) would be much needed for the early diagnosis, prevention and treatment of insulin resistance. The proposed studies will aim to provide new adipose tissue-derived blood biomarkers and mathematical models that could provide a better prediction of insulin resistance in obese people than current commonly used surrogate biomarker (HOMA-IR). The anticipated outcome of these studies will address important gaps in our knowledge that could improve clinical practice and early diagnosis of insulin resistance in obese people. Furthermore, this proposal will provide therapeutic and mechanistic insights into obesity-induced insulin resistance.