Research - 2010s
Grants by the Longer Life Foundation have supported hundreds of academicians and scientists engaged in fundamental research into longevity and health. LLF-supported research investigations produce groundbreaking results as well as substantial subsequent support by major research institutions.
Since LLF’s founding in 1998:
investigations have been funded.
peer-reviewed research articles have been published, citing LLF support.
Our Mission: The Longer Life Foundation’s mission is to fund and support the study of factors that either predict the mortality and morbidity of select populations or influence improvements in longevity, health, and wellness.
View All Longer Life Foundation Grants
2019
AWARDED: 2019
Dietary Protein and Cardiovascular Health
Longevity Research Program, Bettina Mittendorfer, Ph.D.
Investigation Year: 1 of 3
AWARDED: 2019
Reducing the Risk of Blood Cancer with Age by Weeding Out Leukemia-Causing Stem Cells in the Bone Marrow
Grant Challen, Ph.D.
Investigation Year: 2 (of 2)
AWARDED: 2019
Leveraging Adaptive Hepatic Glucose Fasting Responses Against Cardiometabolic Disease
Brian DeBosch, M.D., Ph.D.
Investigation Year: 2 of 2
AWARDED: 2019
Restoring Proteostasis to Counter Human Disease
Meredith Jackrel, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2019
Myocardial Aging as a B lymphocyte Dependent Event
Luigi Adamo, M.D., Ph.D.
Investigation Year: 1
AWARDED: 2019
C3(H2O) as a Marker of Human Malignancy
Michelle Elvington, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2019
A Pathogenic Role for Senescent Schwann Cells in the Aging-Associated Impairment of Nerve Regeneration
Sungsu Kim, Ph.D.
Investigation Year: 1
AWARDED: 2019
Innovative Data Mining for Biological Age
Lei Liu, Ph.D.
Investigation Year: 1
AWARDED: 2019
Targeting Cutibacterium Acnes RoxP to Decrease Morbidity and Mortality of Indwelling Medical Devices
William McCoy, M.D., Ph.D.
Investigation Year: 1
AWARDED: 2019
Predicting Cardiovascular Toxicity of Targeted Cancer Therapy
Josh Mitchell, M.D., FACC
Investigation Year: 1
2018
AWARDED: 2018
Complex Interaction Between Excess Adiposity and Healthy Aging
Samuel Klein, M.D., Ph.D.
Director, Longevity Research Program
Investigation Year: 1
AWARDED: 2018
The Trajectory of the Fecal Microbiome in Patients with Multidrug-Resistant Urinary Tract Infections
Jennie Kwon, D.O.
Investigation Year: 2
AWARDED: 2018
Role of CD36 in Obesity-Associated Fatty Liver Disease and Hepatic Insulin Resistance
Dmitri Samovski, Ph.D.
Investigation Year: 2 (of 2)
AWARDED: 2018
Restoring Proteostasis to Counter Human Disease
Meredith Jackrel, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2018
Reducing the Risk of Blood Cancer With Age By Weeding Out Leukemia-Causing Stem Cells in the Bone Marrow
Grant Challen, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2018
Leveraging Adaptive Hepatic Glucose Fasting Responses Against Cardiometabolic Disease
Brian DeBosch, M.D., Ph.D.
Investigation Year: 1
2017
AWARDED: 2017
Nicotine N-Oxidation, A Novel Target for Smoking Cessation
Joseph Bloom, Ph.D.
Investigation Year: 1
AWARDED: 2017
Examining the Contribution of Diabetes and Obesity to Alzheimer’s Disease
Brian Gordon, Ph.D.
Investigation Year: 1
AWARDED: 2017
The Trajectory of the Fecal Microbiome in Patients with Multidrug-Resistant Urinary Tract Infections
Jennie Kwon, D.O.
Investigation Year: 1 of 2
AWARDED: 2017
Role of CD36 in Obesity-Associated Fatty Liver Disease and Hepatic Insulin Resistance
Dmitri Samovski, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2017
The Structural and Functional Brain Network in Early- and Later-Onset Depressive Disorder
Faye Womer, M.D.
Investigation Year: 1
AWARDED: 2017
The Impact of Progressive Telomere Shortening on Mitochondria Function and Energy Metabolism
Luis Batista, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2017
Precision Therapeutics for Pediatric Dilated Cardiomyopathy (DCM)
Kory Lavine, M.D. Ph.D.
Investigation Year: 2 of 2
AWARDED: 2017
Metabolic and Molecular Effects of Prolonged Fasting
Luigi Fontana, M.D., Ph.D.
Investigation Year: 1
2016
AWARDED: 2016
Citrulline as Potential Insulin Sensitizer and Longevity Factor
Thomas J. Baranski, M.D., Ph.D.
Investigation Year: 1
AWARDED: 2016
The Impact of Progressive Telomere Shortening on Mitochondria Function and Energy Metabolism
Luis Batista, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2016
Age-Specific Mechanisms Drive the Pathogenesis of Human Heart Failure
Kory Lavine, M.D. Ph.D.
Investigation Year: 1 of 2
AWARDED: 2016
Identification of Novel Blood Biomarkers and Mediators of Obesity-induced Insulin Resistance
Jun Yoshino, M.D., Ph.D.
Investigation Year: 2 of 2
AWARDED: 2016
Identification of Human Genetic Variants for High Risk of Severe Influenza Disease
Adrianus Boon, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2016
Remote Detection of TP53 and ß-catenin Mutations in Liver Cancer
Yiing Lin, M.D. Ph.D.
Investigation Year: 2 of 2
AWARDED: 2016
Using Anti-Viral Biomarkers to Predict Breast Cancer Aggressiveness
Jason D. Weber, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2016
Metabolic and Molecular Effects of Intermittent Fasting and Mediterranean Diet
Director: John O. Holloszy, M.D.
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 1
2015
AWARDED: 2015
Longevity Research Program: Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 3 of 3
AWARDED: 2015
Functional Dissection of Age-Related Differences in Disease: Phenotype in Polycythemia Vera
Stephen Oh, M.D., Ph.D.
Investigation Year: 1
AWARDED: 2015
Using Anti-viral Biomarkers to Predict Breast Cancer Aggressiveness
Jason D. Weber, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2015
Identification of Novel Blood Biomarkers and Mediators of Obesity-induced Insulin Resistance
Jun Yoshino, M.D., Ph.D.
Investigation Year: 1 of 2
AWARDED: 2015
Early-Adulthood Predictors of Mortality and Morbidity
Zachary Pincus, Ph.D.
Investigation Year: 1
AWARDED: 2015
snoRNAs and Long-Term Risk of Diabetic Complications
Jean E. Schaffer, M.D.
Investigation Year: 2 of 2
AWARDED: 2015
A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer
Matt Ciorba, M.D.
Investigation Year: 2 of 2
AWARDED: 2015
Identification of Human Genetic Variants for High Risk of Severe Influenza Disease
Adrianus Boon, Ph.D.
Investigation Year: 1 of 2
2014
AWARDED: 2014
Does Intermittent Fasting Mimic the Anti-Aging Benefits of Calorie Restriction in Humans?
Director: John O. Holloszy, M.D.
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 1
AWARDED: 2014
A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients with Clinical T1-2 N0M0 Invasive Breast Cancer and Negative Axillary Ultrasound
Amy E. Cyr
Investigation Year: 2 of 2
AWARDED: 2014
Discovery of Urinary Tract Infection Biomarkers to Predict Longevity in the Elderly
Jeffrey Henderson, M.D. Ph.D.
Investigation Year: 2 of 2
AWARDED: 2014
Effect of Dietary Macronutrient Composition on Glycemic Control and Cardiovascular Risk Factors
Dominic N. Reeds, M.D.
Investigation Year: 2 of 2
AWARDED: 2014
Plasma DNA Mutations as Biomarkers of Hepatocellular Carcinoma
Yiing Lin, M.D. Ph.D.
Investigation Year: 1 of 2
AWARDED: 2014
snoRNAs and Long-term Risk of Diabetic Complications
Jean E. Schaffer, M.D.
Investigation Year: 1 of 2
AWARDED: 2014
Prognostic and Therapeutic Value of Nuclear pSer137-Pfn1 for Breast Cancer
Jieya Shao, Ph.D.
Investigation Year: 1
2013
AWARDED: 2013
Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?
Investigation Year: 2 of 3
AWARDED: 2013
A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients With T1-T2 Invasive Breast Cancer and Negative Axillary Ultrasound
Amy E. Cyr, M.D.
Investigation Year: 1 of 2
AWARDED: 2013
Discovery of Urinary Tract Infection Biomarkers to Predict Longevity in the Elderly
Jeffrey Henderson, M.D. Ph.D.
Investigation Year: 1 of 2
AWARDED: 2013
Long-Term Prognostic Value of Novel Cardiac Biomarkers After Cardiac Stress Echocardiography (Testing)
Peter Nagele, M.D.
Investigation Year: 1
AWARDED: 2013
Effects of dietary macronutrient composition on glycemic control and cardiovascular risk factors
Dominic N. Reeds, M.D.
Investigation Year: 1 of 2
2012
AWARDED: 2012
Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?
Director: John Holloszy, M.D.
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 1 of 3
AWARDED: 2012
A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer
Matt Ciorba, M.D.
Investigation Year: 1 of 2
AWARDED: 2012
CD36 Variants and Stroke Risk Factors
Latisha Love-Gregory, Ph.D
Investigation Year: 2 of 2
AWARDED: 2012
A Pilot Study of Adipokines and Caloric Restriction in Patients with Multiple Sclerosis
Laura Piccio, M.D. Ph.D.
Investigation Year: 1
AWARDED: 2012
Use of Alzheimer’s Disease Biomarkers to Predict Longevity and Disability
Catherine Roe, Ph.D.
Investigation Year: 2 of 2
AWARDED: 2012
Monomethyl Branched Chain Fatty Acids (mmBCFAs) as Potential Biomarkers for Risk of Obesity-Associated Metabolic Disease
Xiong Su, Ph.D.
Investigation Year: 1
AWARDED: 2012
Effects of Increased Dietary High-Fructose Corn Syrup on Intrahepatic Triglyceride Content and Lipoprotein Kinetics in People with a Non-Alcoholic Fatty Liver Disease
Shelby Sullivan, M.D.
Investigation Year: 2 of 2
AWARDED: 2012
Is Aging and its Associated Co-morbidities Due to Diminished Autophagy?
Conrad Weihl, M.D., Ph.D.
Investigation Year: 1
AWARDED: 2012
Survival, Disease Co-morbidity, and Assessment of Novel and Genetic Variants for Risk Prediction in the NHLBI Family Heart Study (FamHS)
Mary Kaye Wojczynski, Ph.D.
Investigation Year: 1
2011
AWARDED: 2011
Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?
Director: John O. Holloszy, M.D.
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 2 of 2
AWARDED: 2011
Determination of the Genetic Contribution to Glycemic Control and CAD Outcomes in Patients with DM2 and CAD
Sharon Cresci, M.D.
Investigation Year: 2 of 2
AWARDED: 2011
Assessment of Potential Novel Immune Biomarkers to Identify Obese Persons at Increased Risk for Cardiometabolic Disease
Elisa Fabbrini, M.D., Ph.D.
Investigation Year: 2 of 2
AWARDED: 2011
CD36 Variants and Stroke Risk Factors
Latisha Love-Gregory, Ph.D.
Investigation Year: 1 of 2
AWARDED: 2011
Improving Presymptomatic Detection of Impending Alzheimer’s Disease
Catherine Roe, Ph.D.
Investigation Year: 1
2010
AWARDED: 2010
Does a Low Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?
Longevity Research Program:
Director: John O Holloszy, M.D.
Co-Director: Luigi Fontana, M.D. Ph.D.
Investigation Year: 2 of 2
AWARDED: 2010
Predicting Prognosis in Invasive Breast Cancer by Genetic Instability
D. Craig Allred, M.D.
Investigation Year: 1
AWARDED: 2010
Does Caloric Restriction Slow Aging of the Human Immune System?
Marco Colonna, M.D.
Investigation Year: 2 of 2
AWARDED: 2010
Determination of the Genetic Contribution to Glycemic Control and CAD Outcomes in Patients with DM2 and CAD
Sharon Cresci, M.D.
Investigation Year: 1 of 2
AWARDED: 2010
Assessment of Potential Novel Immune Biomarkers to Identify Obese Persons at Increased Risk for Cardiometabolic Disease
Elisa Fabbrini, M.D. Ph.D.
Investigation Year: 1 of 2
AWARDED: 2010
Calorie Restriction and Metabolic Health in Older Adults
Bettina Mittendorfer, Ph.D.
Investigation Year: 1