LLF also funds the Longevity Research Program, which studies the physiological effects of ongoing calorie restriction upon the human body and analyzes the implications of its findings for aging and longevity.
Awarded: 2019
Dietary protein and cardiovascular health
Bettina Mittendorfer, Ph.D., Longevity Research Program
Investigation Year: 1st Year
Reducing the risk of blood cancer with age by weeding out leukemia-causing stem cells in the bone marrow
Grant Challen, Ph.D.
Investigation Year: 2nd Year
Leveraging adaptive hepatic glucose fasting responses against cardiometabolic disease
Brian DeBosch, M.D., Ph.D.
Restoring proteostasis to counter human disease
Meredith E. Jackrel, Ph.D.
Myocardial aging as a B lymphocyte dependent event
Luigi Adamo, M.D., Ph.D.
C3(H2O) as a marker of human malignancy
Michelle Elvington, Ph.D.
A pathogenic role for senescent Schwann cells in the aging-associated impairment of nerve regeneration
Sungsu Kim, Ph.D.
Innovative data mining for biological age
Lei Liu, Ph.D.
Targeting Cutibacterium acnes RoxP to decrease morbidity and mortality of indwelling medical devices
William McCoy, M.D., Ph.D.
Predicting cardiovascular toxicity of targeted cancer therapy
Josh Mitchell, M.D., FACC Investigation Year: 1st Year
Awarded: 2018
Complex Interaction Between Excess Adiposity and Healthy Aging
Samuel Klein, M.D., Director, Longevity Research Program
The Trajectory of the Fecal Microbiome in Patients with Multidrug-Resistant Urinary Tract Infections (UTIs)
Jennie Kwon, D.O.
Role of CD36 in the Obesity-Associated Fatty Liver Disease and Hepatic Insulin Resistance
Dmitri Samovski, Ph.D.
Restoring Proteostasis to Counter Human Disease
Reducing the Risk of Blood Cancer with Age by Weeding Out Leukemia-Causing Stem Cells in the Bone Marrow
Leveraging Adaptive Hepatic Glucose Fasting Responses Against Cardiometabolic Disease
Brian DeBosch, Ph.D.
Awarded: 2017
Nicotine N-Oxidation, a Novel Target for Smoking Cessation
A. Joseph Bloom, Ph.D.
Examining the Contribution of Diabetes and Obesity to Alzheimer's Disease
Brian Gordon, Ph.D.
The Structural and Functional Brain Network in Early- and Later-Onset Depressive Disorder
Faye Womer, M.D.
The Impact of Progressive Telomere Shortening on Mitochondria Function and Energy Metabolism
Luis Batista, Ph.D.
Precision Therapeutics for Pediatric Dilated Cardiomyopathy (DCM)
Kory Lavine, M.D., Ph.D.
Metabolic and Molecular Effects of Prolonged Fasting
Longevity Research Program: Luigi Fontana, M.D., Ph.D.
Awarded: 2016
Citrulline as Potential Insulin Sensitizer and Longevity Factor
Thomas J. Baranski, M.D., Ph.D.
Age-Specific Mechanisms Drive the Pathogenesis of Human Heart Failure
Identification of Novel Blood Biomarkers and Mediators of Obesity-Induced Insulin Resistance
Jun Yoshino, M.D., Ph.D.
Identification of Human Genetic Variants for High Risk of Severe Influenza Disease
Adrianus Boon, Ph.D.
Remote Detection of TP53 and ß-catenin Mutations in Liver Cancer
Yiing Lin, M.D., Ph.D.
Using Anti-Viral Biomarkers to Predict Breast Cancer Aggressiveness
Jason Weber, Ph.D.
Metabolic and Molecular Effects of Intermittent Fasting and Mediterranean Diet
Awarded: 2015
Does Intermittent Fasting Mimic the Anti-Aging and Health Benefits of Calorie Restriction in Humans?
Longevity Research Program: John Holloszy, M.D., Director Luigi Fontana, M.D. Ph.D., Assoc. Dir.
Functional Dissection of Age-Related Differences in Disease Phenotype in Polycythemia Vera
Stephen Oh, M.D., Ph.D.
Jason D. Weber, Ph.D.
Early-Adulthood Predictors of Mortality and Morbidity
Zachary Pincus, Ph.D.
snoRNAs and Long-Term Risk of Diabetic Complications
Jean E. Schaffer, M.D.
A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestinal Cancer
Matt Ciorba, M.D.
Awarded: 2014
Long-Term Health Benefits of Caloric Restriction: Does Intermittent Fasting Mimic the Anti-Aging Benefits of Calorie Restriction in Humans?
Longevity Research Program; John Holloszy, M.D., Director; and Luigi Fontana, M.D. Ph.D., Associate Director
A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients with Clinical T1-2 N0M0 Invasive Breast Cancer and Negative Axillary Ultrasound
Amy E. Cyr, M.D.
Discovery of Urinary Tract Infection Biomarkers to Predict Longevity in the Elderly
Jeffrey Henderson, M.D. Ph.D.
Effect of Dietary Macronutrient Composition on Glycemic Control and Cardiovascular Risk Factors
Dominic N. Reeds, M.D.
Plasma DNA Mutations as Biomarkers of Hepatocellular Carcinoma
Yiing Lin, M.D. Ph.D.
Prognostic and Therapeutic Value of Nuclear pSer137-Pfn1 for Breast Cancer
Jieya Shao, Ph.D.
Awarded: 2013
Long-Term Health Benefits of Calorie Restriction; Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?
Longevity Research Program: John Holloszy M.D., Director Luigi Fontana M.D., Ph.D., Associate Director
Investigation Year: 4th Year
A Prospective, Randomized Trial of Sentinel Lymph Node Biopsy Versus No Additional Staging in Patients with Clinical T1-2 N0 M0 Invasive Breast Cancer and Negative Axillary Ultrasound
Long-Term Prognostic Values of Novel Cardiac Biomarkers After Cardiac Stress Echocardiography (Testing)
Peter Nagele, M.D.
Effects of Dietary Macronutrient Composition on Glycemic Control and Cardiovascular Risk Factors
Awarded: 2012
Investigation Year: 3rd Year
A Randomized Control Trial of the Probiotic LGG for Prevention of Side Effects in Patients Undergoing Chemoradiation for Gastrointestional Cancer
CD36 Variants and Stroke Risk Factors
Latisha Love-Gregory, Ph.D.
A Pilot Study of Adipokines and Caloric Restriction in Patients with Multiple Sclerosis
Laura Piccio, M.D., Ph.D.
Use of Alzheimer's Disease Biomarkers to Predict Longevity and Disability
Catherine Roe, Ph.D.
Monomethyl Branched Chain Fatty Acids (mmBCFAs) as Potential Biomarkers for Risk of Obesity-Associated Metabolic Disease
Xiong Su, Ph.D.
Effects of Increased Dietary High-Fructose Corn Syrup on Intrahepatic Triglyceride Content and Lipoprotein Kinetics in People with a Non-Alcoholic Fatty Liver Disease
Shelby Sullivan, M.D.
Is Aging and its Associated Co-morbidities Due to Diminished Autophagy?
Conrad Weihl, M.D., Ph.D.
Survival, Disease Co-morbidity, and Assessment of Novel and Genetic Variants for Risk Prediction in the NHLBI Family Heart Study (FamHS)
Mary Kaye Wojczynski, Ph.D.
Awarded: 2011
Does a Low-Protein Diet Slow Aging, Protect Against Cancer and Inhibit Prostate Cancer Growth?
Determination of the Genetic Contribution to Glycemic Control and CAD Outcomes in Patients with DM2 and CAD
Sharon Cresci, M.D.
Assessment of Potential Novel Immune Biomarkers to Identify Obese Persons at Increased Risk for Cardiometabolic Disease
Elisa Fabbrini, M.D., Ph.D.
Improving Presymptomatic Detection of Impending Alzheimer's Disease
Awarded: 2010
Predicting Prognosis in Invasive Breast Cancer by Genetic Instability
D. Craig Allred, M.D.
Does Caloric Restriction Slow Aging of the Human Immune System?
Marco Colonna, M.D.
Calorie Restriction and Metabolic Health in Older Adults
Bettina Mittendorfer, Ph.D.
Awarded: 2009
Longer Life Foundation Longevity Research Program
John Holloszy M.D., Director Luigi Fontana M.D., Ph.D., Associate Director
Diagnostic and Therapeutic Applications of a Novel Plasma Metabolite, Nicotinamide Mononucleotide (NMN), for Age-Associated Metabolic Complications in Humans
Shin-ichiro Imai, M.D., Ph.D.
Novel Proteins as Urinary Biomarkers of Renal Cell Carcinoma
Jeremiah Morrissey, Ph.D. and Evan D. Kharasch, M.D., Ph.D.
Novel Methods for Detection of Coronary Artery Disease in Diabetic Patients
Ravi Rasalingam, M.D.
MicroRNA Expression Signatures to Predict Cervical Cancer Outcome
Xiaowei Wang, Ph.D.
Awarded: 2008
Fitness-to-Drive in Older Adults with Stroke
David B. Carr, M.D.
Modulation of Aging and Calorie Restriction Benefits by PGC-1α
John J. Lehman, M.D.
Omega-3 Fatty Acids for the Treatment of the Anabolic Resistance of Skeletal Muscle in Older Adults
Identification of Significant Coronary Artery Disease at Rest with Integrated Backscatter Imaging and Myocardial Strain
Ravi Rasalingan, M.D.
Awarded: 2007
Fitness-to-Drive in Neurologically Impaired Older Adults
Effects of Calorie Restriction on Markers of Aging and Longevity
Luigi Fontana, M.D. Ph.D.
Undercarboxylated Matrix Gla Protein (ucMGP): a Novel Biomarker to Predict Coronary Artery Calcification
Tusar K. Giri, M.D., Ph.D. Brian F. Gage, M.D. M.Sc.
Dependence of Longevity and Health on TRB3 Genotype
Comprehensive Assessment of Senior Adult Cancer Patients
Jay F. Piccirillo, M.D.
Awarded: 2006
Luigi Fontana, M.D., Ph.D.
Minimally Invasive Staging of the Axilla in Breast Cancer
Julie A. Margenthaler, M.D.
Anthony J. Muslin, M.D.
International Collaborative Study of Social Support
Edwin B. Fisher, Ph.D.
Awarded: 2005
Mental Health History and Survival Among Breast Cancer Patients
Mark S. Walker, Ph.D.
Regulation of Longevity by Anticonvulsant Medicines
S. Kerry Kornfeld, M.D.
Activity Portfolios: Engagement and Health in Later Life
Nancy L. Morrow-Howell, Ph.D.
The Effect of the C488&A Polymorphism of the CYP1A1 Gene on Cognitive Function
Reina C. Villareal, M.D.
Collection of Preliminary Data on the Interaction of Social Engagement and Stress in Older Adults
Dorothy Edwards, Ph.D.
Environmental Features that Influence Social Engagement of Older Adults Residing in Congregate Living Facilities
Susan L. Stark, Ph.D.
Effects of Allocation of Attention on Habituation to Olfactory and Visual Food Stimuli in Obese Children
Denise E. Wilfley, Ph.D.
Awarded: 2004
Food For Thought: An Internet-Based Treatment Program for Childhood Obesity
Jane Garbutt, M.B., Ch.B.
Ginseng in Prevention and Treatment of Diabetes
Kenneth S. Polonsky, M.D.
Development of Multidisciplinary Approach to Obesity
Samuel Klein, M.D.
Projecting Individualized Cancer-Specific Death Risks and Other Competing Cause Death Risks Among Elderly Men Diagnosed with Prostate Cancer
Yan Yan, M.D., M.H.S., Ph.D.
Inflammatory Cytokines and Physical Frailty in Obese Elderly Subjects
Dennis T. Villareal, M.D.
Early Intervention of Eating- and Weight-Related Problems Via the Internet in Overweight Adolescents: A Randomized Controlled Trial
Awarded: 2003
Edwin S. Fisher, Ph.D.
The Key Features Inventory: Early Diagnosis of Dementia to Improve Quality of Life
James E. Galvin, M.D.
Pharmacologic Compounds that Extend C. elegans Life Span
S. Kerry Kornfeld, M.D. Ph.D.
Influence of Exercise and Dietary Patterns on Weight Gain Throughout College
Susan S. Deusinger, Ph.D. Susan B. Racette, Ph.D.
Predictors of Survival in Patients with Primary Pulmonary Hypertension Wait-Listed for Lung Transplantation
Roger D. Yusen, M.D., M.P.H.
Awarded: 2002
Long-Term Adjustment and Quality of Life Among Breast Cancer Survivors Following Treatment
Tiffany L. Tibbs, Ph.D. Teresa L. Deshields, Ph.D.
Physician-Related Barriers to Colorectal Cancer Screening in Missouri
Dayna S. Early, M.D.
Markers of Cognitive Change in an Aging Population
Psychosocial Factors Associated with Delay in Diagnosis Among Locally Advanced Breast Cancer Patients
Donna B. Jeffe, Ph.D.
Abdominal Pain Evaluation Tool (APET) (Pilot Project)
Lawrence M. Lewis, M.D.
Awarded: 2001
Risk Adjustment in the Medicare Atrial Fibrillation Population
Brian F. Gage, M.D. M.Sc. Amy Doggette Waterman, Ph.D.
Data Mining Approaches to Suicide and Suicidal Behaviors
Rumi Kato Price, Ph.D., M.P.E.
Disease Comorbidity and Survival in the NHLBI Family Heart Study
Michael A. Province, Ph.D.
Awarded: 2000
Health-Related Quality of Life: A Strategy for Improving Physician-Patient Communication and Patient Outcomes
Thomas E. Burroughs, Ph.D.
Productive Engagement in Older Adults: Effects on Well-Being and Mortality
Breast Cancer Screening and Disability
Mario Schootman, Ph.D.
Enhanced Diabetes Self-Management Using Peer Health Coaches
Kathleen L. Tarr, M.D., Ph.D.
Awarded: 1999
Cancer Patient-Specific Prognostic Information